Cross-linguistic exploration of phonemic representations

All languages around the world have their own vast sound inventories. Understanding each other through verbal communication requires, first of all, understanding each other\u2019s phonemes. This often overlooked constraint is non-trivial already among native speakers of the same language, given the variability with which we all articulate our phonemes. It becomes even more challenging when interacting with non-native speakers, who have developed neural representations of different sets of phonemes. How can the brain make sense of such diversity? It is remarkable that the sounds produced by the vocal tract, that have evolved to serve as sym-bols in natural languages, fall almost neatly into two classes with such different characteristics, consonants and vowels. Consonants are complex in nature: beyond acoustically-defined formant (resonant) frequencies, additional physical parameters such as formant transitions, the delay period in those transitions, energy bursts, the vibrations of the vocal cords occurring before and during the consonant burst, and the length of those vibrations are needed to identify them. Surprisingly, consonants are very quickly categorized through a quite mysterious form of invariant feature ex-traction. In contrast to consonants, vowels can be represented in a simple and transparent manner and that is because, amazingly, only two analog dimensions within a continuous space are essen-tially enough to characterize a vowel. The first dimension corresponds to the degree to which the vocal tract is open when producing the vowel and the second dimension is the location of the main occlusion. Surprisingly, these anatomically-defined production modes match very precisely the first two acoustically-defined formant frequencies, namely F1 and F2. While for some languages some additional features are necessary to specify a vowel, such as its length or roundedness, whose nature may be more discrete, for many others F1 and F2 are all there is to it. In this thesis, we use both behavioral (phoneme confusion frequencies) and neural measures (the spatio- temporal distribution of phoneme-evoked neural activation) to study the cross-linguistic organization of phoneme perception. In Chapter 2, we study the perception of consonants by repli-cating and extending a classical study on sub-phonemic features underlying perceptual differences between phonemes. Comparing the responses of native listeners to that of Italian, Turkish, Hebrew, and (Argentinian) Spanish listeners to a range of American English consonants, we look at the specific patterns of errors that speakers of different languages make by using the metric content index, which was previously used in entirely different contexts, with either discrete, e.g. in face space, or continuous representations, e.g. of the spatial environment. Beyond the analysis of percent correct score, and transmitted information, we frame the problem in terms of \u2018place attractors\u2019, in analogy to those which have been well studied in spatial memory. Through our experimental paradigm, we try to access distinct attractors in different languages. In the same chapter, we provide auditory evoked potentials of some consonant-vowel syllables, which hint at transparent processing of the vowels regulated by the first two formants that characterize them, and accordingly we then turn to investigating the vowel trajectories in the vowel manifold. We start our exploration of the vowel space in Chapter 3 by addressing a perceptually important third dimension for native Turkish speakers \u2013 that is rounding. Can native Turkish speakers navigate better vowel trajectories in which the second formant changes over a short time, to reflect rounding, compared to native Italian speakers, who are not required to make such fine discriminations on this dimension? We found no mother tongue effects. We have found, however, that rounding in vowels could be represented with similar efficiency by fine differences in a F2 peak frequency which is constant in time, or inverting the temporal dynamics of a changing F2, which then makes vowels not mere points in the space, but rather continuous trajectories.We walk through phoneme trajectories at every tens of milliseconds, it comes to us as nat-urally as walking in a room, if not more. Similar to spatial trajectories, we create equidistant continuous vowel trajectories in Chapter 4 on a vowel wheel positioned in the central region of the two-dimensional vowel space where in some languages like Italian there are no standard vowel categories, and in some other, like English, there are. Is the central region in languages like Italian to be regarded as a flat empty space with no attractors? Is there any reminiscence of their own phoneme memories? We ask whether this central region is flat, or can at least be flattened through extensive training. If so, would then we find a neural substrate that modulates the perception in the 2D vowel plane, similar to grid cell representation that is involved in the spatial navigation of empty 2D arenas? Our results are not suggestive of a grid-like representation, but rather points at the modulation of the neural signal by the position of Italian vowels around the outer contour of the wheel. Therefore in Chapter 5, we ask how our representation of the vowel space, not only in the central region but rather in the entirely of its linguistically relevant portion, is deformed by the presence of the standard categories of our vowel repertoire. We use \u2018belts\u2019, that are short stretches along which formant frequencies are varied quasi-continuously, to determine the local metric that best describes, for each language, the vowel manifold as a non-flat space constructed in our brain. As opposed to the \u2018consonant planes\u2019, that we constructed in Chapter 2, which appear to have a similar structure to a great extent, we find that the vowel plane is subjective and that it is language dependent. In light of language-specific transformations of the vowel plane, we wonder whether native bilinguals hold simultaneously multiple maps available and use one or the other to interpret linguistic sources depending on context. Or alternatively, we ask, do they construct and use a fusion of the two original maps, that allows them to efficiently discriminate vowel contrast that have to be discriminated in either language? The neural mechanisms underlying the physical map switch, known as remapping, have been well studied in rodent hippocampus; is the vowel map alternation governed by similar principles? We compare and show that the perceptual vowel maps of native Norwegian speakers, who are not bilingual but fluent in English, are unique, probably sculpted by their long-term memory codes, and we leave the curious case of bilinguals for future studies. Overall we attempt to investigate phoneme perception in a different framework compared to how it has been studied in the literature, which has been in the interest of a large community for many years, but largely disconnected from the study of cortical computation. Our aim is to demonstrate that insights about persisting questions in the field may be reached from another well explored part of cognition

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)

Picturing asthma in Turkey: results from the Turkish adult asthma registry

Introduction: National data on asthma characteristics and the factors associated with uncontrolled asthma seem to be necessary for every country. For this purpose, we developed the Turkish Adult Asthma Registry for patients with asthma aiming to take a snapshot of our patients, thereby assigning the unmet needs and niche areas of intervention. Methods: Case entries were performed between March 2018 and March 2022. A web-based application was used to record data. Study outcomes were demographic features, disease characteristics, asthma control levels, and phenotypes. Results: The registry included 2053 patients from 36 study centers in Turkey. Female subjects dominated the group (n = 1535, 74.8%). The majority of the patients had allergic (n = 1158, 65.3%) and eosinophilic (n = 1174, 57.2%) asthma. Six hundred nineteen (32.2%) of the patients had obese asthma. Severe asthma existed in 670 (32.6%) patients. Majority of cases were on step 3–5 treatment (n: 1525; 88.1%). Uncontrolled asthma was associated with low educational level, severe asthma attacks in the last year, low FEV1, existence of chronic rhinosinusitis and living in particular regions. Conclusion: The picture of this registry showed a dominancy of middle-aged obese women with moderate-to-severe asthma. We also determined particular strategic targets such as low educational level, severe asthma attacks, low FEV1, and chronic rhinosinusitis to decrease uncontrolled asthma in our country. Moreover, some regional strategies may also be needed as uncontrolled asthma is higher in certain regions. We believe that these data will guide authorities to reestablish national asthma programs to improve asthma service delivery